Development and Market Objectives

Lung cancer has the highest incidence rate and 85% of lung cancer patients are classified as NSCLC. The 10-year survival rate of lung cancer patients is less than 10%.

Current first-line treatment decisions for advanced NSCLC are based on the presence of genetic aberrations, such as sensitizing mutations of EGFR and translocations of ALK. However, most patients with NSCLC do not harbor these oncogenic drivers, and for these patients, treatment options are limited cytotoxic chemotherapy.

Anti-PD-1 and anti-PD-L1 antibodies produced durable responses in approximately 20% of unselected patients with advanced NSCLC. They only benefit a fraction of patients and there is urgent need for novel NSCLC treatments.

Unmet Medical Need & Target Patients

Novel B7-H3 targeting antibodies were developed by Y-Biologics, a joint research company.

Novel B7-H3 ADCs were generated by conjugating lead antibody to various drug payloads with OHPAS linker technology.

The resulting ADCs showed very potent activity against B7-H3 positive cancer cells.

Current Progress

Novel B7-H3 targeting antibodies were developed by Y-Biologics, a joint research company.

Novel B7-H3 ADCs were generated by conjugating lead antibody to various drug payloads with OHPAS linker technology.

The resulting ADCs showed very potent activity against B7-H3 positive cancer cells.

In vivo POC of B7-H3 ADCs was confirmed in human breast cancer mouse xenograft model (JIMT-1, B7-H3 overexpressed).

Intellectual Property

Patent applications were submitted for novel OHPAS linker and benzodiazepine payloads.

Key OHPAS patent has been published in Korea as of January 2019 and has been filed in USA, PCT (Application No. KR 10-2018-0076708 ; PCT/IB2018/000847 ; US 62/597,226).

B7-H3 ADC patent will be applied after lead ADCs are selected.

Competitive Advantages

Novel self-immolative OHPAS linker and ultra-potent benzodiazepine payload technologies are employed in B7-H3 ADCs.

  - highly stable in chemical and biological environment

  - efficiently liberating appended payload in target cancer cells and demonstrating excellent potencies in vivo

  - possibly able to broaden the therapeutic window by avoiding premature payload release in circulation

  - Site-specifically drug conjugated

Disease Target

Lung Cancer

Project duration

2019.02.01-2020.06.30

Organization

IntoCell, Inc.

Phase of Development

hit to lead

Contact

• Organization: IntoCell, Inc.
• Website: http://www.intocell.co.kr
• Contact Person: Hyangsook Lee/Biology Director
• E-mail: hslee@intocell.co.kr
• Phone No.: +82-42-716-0083

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